USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: CDC42_HUMAN USC-OGP 2-DE database:  CDC42_HUMAN CDC42_HUMAN General information about the entry View entry in simple text format Entry name CDC42_HUMAN Primary accession number P60953 Secondary accession number(s) P25763 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Cell division control protein 42 homolog; AltName: Full=G25K GTP-binding protein; Flags: Precursor;. Gene name Name=CDC42 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0554: pI=6.15; Mw=21863 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1034: pI=6.12; Mw=22144 SPOT OGP-1039: pI=6.11; Mw=21197 Cross-references UniProtKB/Swiss-Prot P60953; CDC42_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CDC42_HUMAN Primary accession number P60953 Secondary accession number(s) P21181 P25763 Q7L8R5 Q9UDI2 Sequence was last modified on  February 8, 2011 (version 2) Annotations were last modified on  March 15, 2017 (version 172) Name and origin of the protein Description RecName: Full=Cell division control protein 42 homolog; AltName: Full=G25K GTP-binding protein; Flags: Precursor; Gene name Name=CDC42 Encoded on Name=CDC42 Keywords 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Differentiation; Direct protein sequencing; Disease mutation; Glycoprotein; GTP-binding; Lipoprotein; Membrane; Mental retardation; Methylation; Neurogenesis; Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M35543; AAA52494.1; -; mRNA EMBL M57298; AAA52592.1; -; mRNA EMBL AL121734; CAB57325.1; -; mRNA EMBL AL121735; CAB57326.1; -; mRNA EMBL AF498962; AAM21109.1; -; mRNA EMBL AF498963; AAM21110.1; -; mRNA EMBL AY673602; AAT70721.1; -; Genomic_DNA EMBL AL031281; CAB52602.1; -; Genomic_DNA EMBL AL031281; CAD92551.1; -; Genomic_DNA EMBL BC002711; AAH02711.1; -; mRNA EMBL BC003682; AAH03682.1; -; mRNA EMBL BC018266; AAH18266.1; -; mRNA CCDS CCDS221.1; -; . CCDS CCDS222.1; -. [P60953-1]; . PIR A36382; A36382; . PIR A39265; A39265; . RefSeq NP_001034891.1; NM_001039802.1. [P60953-2]; . RefSeq NP_001782.1; NM_001791.3. [P60953-2]; . RefSeq NP_426359.1; NM_044472.2. [P60953-1]; . UniGene Hs.467637; -; . PDB 1A4R; X-ray; 2.50 A; A/B=1-191 PDB 1AJE; NMR; -; A=1-187 PDB 1AM4; X-ray; 2.70 A; D/E/F=2-177 PDB 1AN0; X-ray; 2.80 A; A/B=1-190 PDB 1CEE; NMR; -; A=1-179 PDB 1CF4; NMR; -; A=1-184 PDB 1DOA; X-ray; 2.60 A; A=1-188 PDB 1E0A; NMR; -; A=1-184 PDB 1EES; NMR; -; A=1-178 PDB 1GRN; X-ray; 2.10 A; A=1-191 PDB 1GZS; X-ray; 2.30 A; A/C=1-178 PDB 1KI1; X-ray; 2.30 A; A/C=1-188 PDB 1KZ7; X-ray; 2.40 A; B/D=1-188 PDB 1KZG; X-ray; 2.60 A; B/D=1-188 PDB 1NF3; X-ray; 2.10 A; A/B=2-191 PDB 2ASE; NMR; -; A=1-178 PDB 2DFK; X-ray; 2.15 A; B/D=1-191 PDB 2KB0; NMR; -; A=1-178 PDB 2NGR; X-ray; 1.90 A; A=1-191 PDB 2ODB; X-ray; 2.40 A; A=1-181 PDB 2QRZ; X-ray; 2.40 A; A/B=1-189 PDB 2WM9; X-ray; 2.20 A; B=1-188 PDB 2WMN; X-ray; 2.39 A; B=1-188 PDB 2WMO; X-ray; 2.20 A; B=1-188 PDB 3GCG; X-ray; 2.30 A; A=2-178 PDB 3QBV; X-ray; 2.65 A; A/C=1-178 PDB 3VHL; X-ray; 2.08 A; B=1-188 PDB 4DID; X-ray; 2.35 A; A=1-183 PDB 4ITR; X-ray; 2.30 A; C/D=1-191 PDB 4JS0; X-ray; 1.90 A; A=1-178 PDB 4YC7; X-ray; 2.50 A; A=1-179 PDB 4YDH; X-ray; 3.80 A; B/D=1-179 PDB 5CJP; X-ray; 2.60 A; A/B/C/D=1-177 PDB 5FI1; X-ray; 3.20 A; B=1-191 PDB 5HZK; X-ray; 3.30 A; A/C=1-181 PDBsum 1A4R; -; . PDBsum 1AJE; -; . PDBsum 1AM4; -; . PDBsum 1AN0; -; . PDBsum 1CEE; -; . PDBsum 1CF4; -; . PDBsum 1DOA; -; . PDBsum 1E0A; -; . PDBsum 1EES; -; . PDBsum 1GRN; -; . PDBsum 1GZS; -; . PDBsum 1KI1; -; . PDBsum 1KZ7; -; . PDBsum 1KZG; -; . PDBsum 1NF3; -; . PDBsum 2ASE; -; . PDBsum 2DFK; -; . PDBsum 2KB0; -; . PDBsum 2NGR; -; . PDBsum 2ODB; -; . PDBsum 2QRZ; -; . PDBsum 2WM9; -; . PDBsum 2WMN; -; . PDBsum 2WMO; -; . PDBsum 3GCG; -; . PDBsum 3QBV; -; . PDBsum 3VHL; -; . PDBsum 4DID; -; . PDBsum 4ITR; -; . PDBsum 4JS0; -; . PDBsum 4YC7; -; . PDBsum 4YDH; -; . PDBsum 5CJP; -; . PDBsum 5FI1; -; . PDBsum 5HZK; -; . ProteinModelPortal P60953; -; . SMR P60953; -; . BioGrid 107433; 203; . DIP DIP-31097N; -; . IntAct P60953; 178; . MINT MINT-94609; -; . STRING 9606.ENSP00000314458; -; . BindingDB P60953; -; . ChEMBL CHEMBL6088; -; . DrugBank DB02623; Aminophosphonic Acid-Guanylate Ester; . DrugBank DB04315; Guanosine-5'-Diphosphate; . iPTMnet P60953; -; . PhosphoSitePlus P60953; -; . SwissPalm P60953; -; . BioMuta CDC42; -; . DMDM 322510015; -; . EPD P60953; -; . PaxDb P60953; -; . PeptideAtlas P60953; -; . PRIDE P60953; -; . TopDownProteomics P60953-2; -. [P60953-2]; . DNASU 998; -; . Ensembl ENST00000315554; ENSP00000314458; ENSG00000070831. [P60953-1]; . Ensembl ENST00000344548; ENSP00000341072; ENSG00000070831. [P60953-2]; . Ensembl ENST00000400259; ENSP00000383118; ENSG00000070831. [P60953-2]; . GeneID 998; -; . KEGG hsa:998; -; . UCSC uc001bfp.4; human; . CTD 998; -; . DisGeNET 998; -; . GeneCards CDC42; -; . HGNC HGNC:1736; CDC42; . HPA CAB004360; -; . MalaCards CDC42; -; . MIM 116952; gene; . MIM 616737; phenotype; . neXtProt NX_P60953; -; . OpenTargets ENSG00000070831; -; . PharmGKB PA26266; -; . eggNOG KOG0393; Eukaryota; . eggNOG COG1100; LUCA; . GeneTree ENSGT00760000118978; -; . HOGENOM HOG000233974; -; . HOVERGEN HBG009351; -; . InParanoid P60953; -; . KO K04393; -; . OMA VITIDQG; -; . OrthoDB EOG091G0KCM; -; . PhylomeDB P60953; -; . TreeFam TF101109; -; . Reactome R-HSA-114604; GPVI-mediated activation cascade; . Reactome R-HSA-182971; EGFR downregulation; . Reactome R-HSA-194840; Rho GTPase cycle; . Reactome R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; . Reactome R-HSA-375170; CDO in myogenesis; . Reactome R-HSA-389359; CD28 dependent Vav1 pathway; . Reactome R-HSA-3928662; EPHB-mediated forward signaling; . Reactome R-HSA-416482; G alpha (12/13) signalling events; . Reactome R-HSA-416572; Sema4D induced cell migration and growth-cone collapse; . Reactome R-HSA-418885; DCC mediated attractive signaling; . Reactome R-HSA-428543; Inactivation of Cdc42 and Rac; . Reactome R-HSA-4420097; VEGFA-VEGFR2 Pathway; . Reactome R-HSA-5625970; RHO GTPases activate KTN1; . Reactome R-HSA-5626467; RHO GTPases activate IQGAPs; . Reactome R-HSA-5627123; RHO GTPases activate PAKs; . Reactome R-HSA-5663213; RHO GTPases Activate WASPs and WAVEs; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-983231; Factors involved in megakaryocyte development and platelet production; . SignaLink P60953; -; . SIGNOR P60953; -; . ChiTaRS CDC42; human; . EvolutionaryTrace P60953; -; . GeneWiki CDC42; -; . GenomeRNAi 998; -; . PMAP-CutDB P60953; -; . PRO PR:P60953; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000070831; -; . CleanEx HS_CDC42; -; . ExpressionAtlas P60953; baseline and differential; . Genevisible P60953; HS; . GO GO:0045177; C:apical part of cell; IEA:Ensembl; . GO GO:0005911; C:cell-cell junction; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0043197; C:dendritic spine; IDA:SynGO; . GO GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0030175; C:filopodium; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0000139; C:Golgi membrane; ISS:BHF-UCL; . GO GO:0031256; C:leading edge membrane; IEA:Ensembl; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell; . GO GO:0030496; C:midbody; IDA:UniProtKB; . GO GO:0072686; C:mitotic spindle; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0043005; C:neuron projection; IDA:BHF-UCL; . GO GO:0043025; C:neuronal cell body; IDA:BHF-UCL; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0030141; C:secretory granule; IEA:Ensembl; . GO GO:0051233; C:spindle midzone; IDA:UniProtKB; . GO GO:0000322; C:storage vacuole; IEA:Ensembl; . GO GO:0034191; F:apolipoprotein A-I receptor binding; IPI:BHF-UCL; . GO GO:0005525; F:GTP binding; IDA:UniProtKB; . GO GO:0003924; F:GTPase activity; TAS:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0019901; F:protein kinase binding; IDA:BHF-UCL; . GO GO:0031996; F:thioesterase binding; IPI:UniProtKB; . GO GO:0061630; F:ubiquitin protein ligase activity; IDA:AgBase; . GO GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB; . GO GO:0090135; P:actin filament branching; IEA:Ensembl; . GO GO:0051017; P:actin filament bundle assembly; IEA:Ensembl; . GO GO:0034332; P:adherens junction organization; IEA:Ensembl; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl; . GO GO:0003161; P:cardiac conduction system development; IEA:Ensembl; . GO GO:0032488; P:Cdc42 protein signal transduction; IEA:Ensembl; . GO GO:0034613; P:cellular protein localization; IEA:Ensembl; . GO GO:0036336; P:dendritic cell migration; IEA:Ensembl; . GO GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB; . GO GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome; . GO GO:0090136; P:epithelial cell-cell adhesion; IEA:Ensembl; . GO GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Ensembl; . GO GO:0051683; P:establishment of Golgi localization; ISS:BHF-UCL; . GO GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IEA:Ensembl; . GO GO:0007163; P:establishment or maintenance of cell polarity; TAS:UniProtKB; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:0046847; P:filopodium assembly; IEA:Ensembl; . GO GO:0007030; P:Golgi organization; ISS:BHF-UCL; . GO GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl; . GO GO:0060789; P:hair follicle placode formation; IEA:Ensembl; . GO GO:0060047; P:heart contraction; IEA:Ensembl; . GO GO:0031424; P:keratinization; IEA:Ensembl; . GO GO:0003334; P:keratinocyte development; IEA:Ensembl; . GO GO:0030225; P:macrophage differentiation; TAS:UniProtKB; . GO GO:0099563; P:modification of synaptic structure; IEA:Ensembl; . GO GO:0035264; P:multicellular organism growth; IEA:Ensembl; . GO GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0010629; P:negative regulation of gene expression; IEA:Ensembl; . GO GO:0031333; P:negative regulation of protein complex assembly; IPI:UniProtKB; . GO GO:0048664; P:neuron fate determination; IEA:Ensembl; . GO GO:0007097; P:nuclear migration; IEA:Ensembl; . GO GO:0072384; P:organelle transport along microtubule; ISS:BHF-UCL; . GO GO:0030307; P:positive regulation of cell growth; IMP:AgBase; . GO GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB; . GO GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl; . GO GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl; . GO GO:0051491; P:positive regulation of filopodium assembly; ISS:UniProtKB; . GO GO:0010628; P:positive regulation of gene expression; IEA:Ensembl; . GO GO:0071338; P:positive regulation of hair follicle cell proliferation; IEA:Ensembl; . GO GO:0090316; P:positive regulation of intracellular protein transport; IEA:Ensembl; . GO GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl; . GO GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome; . GO GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl; . GO GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl; . GO GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl; . GO GO:0031274; P:positive regulation of pseudopodium assembly; IDA:UniProtKB; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IDA:UniProtKB; . GO GO:0051835; P:positive regulation of synapse structural plasticity; IEA:Ensembl; . GO GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; IMP:UniProtKB; . GO GO:0051489; P:regulation of filopodium assembly; IDA:UniProtKB; . GO GO:0007088; P:regulation of mitotic nuclear division; IEA:Ensembl; . GO GO:0042176; P:regulation of protein catabolic process; IEA:Ensembl; . GO GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl; . GO GO:0045859; P:regulation of protein kinase activity; IEA:Ensembl; . GO GO:0031647; P:regulation of protein stability; IEA:Ensembl; . GO GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome; . GO GO:0002040; P:sprouting angiogenesis; IEA:Ensembl; . GO GO:0060661; P:submandibular salivary gland formation; IEA:Ensembl; . GO GO:0021762; P:substantia nigra development; IEP:UniProtKB; . GO GO:0031295; P:T cell costimulation; TAS:Reactome; . GO GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0039694; P:viral RNA genome replication; IMP:ParkinsonsUK-UCL; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; NAS:ParkinsonsUK-UCL Gene3D 3.40.50.300; -; 1; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR005225; Small_GTP-bd_dom; . InterPro IPR001806; Small_GTPase; . Pfam PF00071; Ras; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR00231; small_GTP; 1; . PROSITE PS51420; RHO; 1; .

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